| The Comparative Study of Aging and Auditory
Evoked Potentials in the Mouse Model |
| Bin-Na Hong1, Ha-Na Hong2, Jae-Hyeok Lee3, Tong-Ho Kang3 |
1Department of Speech Pathology and Audiology, Nambu University, Gwangju, Korea
2Graduate Program in Audiology, Hallym University, Chuncheon, Korea
3Department of Oriental Pharmaceutical Development, Nambu University, Gwangju, Korea |
| Correspondence |
Tong-Ho Kang ,Tel: +82-62-970-0163, Fax: +82-303-0300-0030, Email: panjae@gmail.com
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Received: May 20, 2007; Accepted: September 14, 2007. Published online: December 31, 2007. |
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| ABSTRACT |
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Objective：Presbycusis is a progressive hearing impairment associated with aging, characterized by hearing loss and a degeneration
of cochlear structures. The mouse has been a useful model of presbycusis, as it displays an accelerated age-related peripheral hearing
loss. The purpose of this study is compared with aging and auditory evoked potentials in the mouse.
Method：Adult male ICR mice
7, 10, 17, 23 and 27 weeks were used in this study. In order to assess age-related hearing loss (AHL), we evaluated auditory
brainstem response (ABR) and auditory middle latency response (AMLR) for the evaluation of sensorineural function in peripheral
auditory nerve.
Results：Hearing thresholds was significantly increased 17, 23 and 27 weeks after birthing comparing with 7 weeks
in the mouse. Pa latency of AMLR was no difference for 6 weeks from 23 weeks group, Absolute latency of wave IV and interpeak
latency of wave I-IV were significantly delayed for 6 weeks from 23 weeks group. The result suggests that significant changes of
auditory evoked potentials from 17 weeks have taken place, age-related hearing loss (AHL) could be evaluated by the shift of
hearing threshold and the increasing of ABR latency in the mouse. |
| Key Words:
Aging·Mouse model·Auditory evoked potential. |
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