| The Validation Study of Otoacoustic Emission by the
Regulation of Body Temperature in the Mouse Model |
| Bin-Na Hong, Tae-Gyu Park, Tong-Ho Kang1 |
1Department of Speech Pathology and Audiology, Gwangju, Korea
2Oriental Pharmaceutical Development, Nambu University, Gwangju, Korea |
| Correspondence |
Tong-Ho Kang ,Tel: +82-62-970-0163, 7459,, Fax: +82-303-0300-0030, Email: panjae@gmail.com
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Received: May 20, 2007; Accepted: October 6, 2007. Published online: December 31, 2007. |
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| ABSTRACT |
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Objective：The otoacoustic emission (OAE) is a useful method for evaluating cochlear function. The aim of this study is the validation
of TEOAE (transiently evoked otoacoustic emission) and DPOAE (Distortion product otoacoustic emissions) by the regulation
of a body temperature in the mouse model.
Method：Adult male ICR mice 7 weeks were used in this study. OAE test were performed
according to body temperature at 34℃, 37℃ and 40℃ respectively. TEOAE and DPOAE were recorded using a
CAPELLA (MADSEN) in the mouse.
Results：In OAE test for the optimization of body temperature, the intensity of TEOAE and
DPOAE was the lowest at 40℃ and the highest at 37℃, but no significantly difference. The 4 kHz DPOAE threshold of normal
temperature was the lowest. The results suggest that the OAE for cochlear function test keep optimal body temperature for good
reliable results in the mouse. |
| Key Words:
Transiently evoked otoacoustic emission (TEOAE)·Distortion product otoacoustic emissions (DPOAE)·
Body temperature·Mouse model. |
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